DelveInsight’s, “Colorectal Cancer Pipeline Insight, 2023,” report provides comprehensive insights about 150+ companies and 150+ pipeline drugs in Colorectal Cancer pipeline landscape. It covers the Colorectal Cancer pipeline drug profiles, including Colorectal Cancer clinical trial and nonclinical stage products. It also covers the Colorectal Cancer pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

 

In the Colorectal Cancer pipeline report, detailed description of the drug is given which includes mechanism of action of the drug, Colorectal Cancer clinical trial studies, Colorectal Cancer NDA approvals (if any), and product development activities comprising the technology, Colorectal Cancer collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

 

Key takeaways from the Colorectal Cancer Pipeline Insight Report

 

• DelveInsight’s colorectal cancer pipeline analysis depicts a robust space with 150+ active players working to develop 150+ pipeline therapies.

 

• The leading Colorectal Cancer pipeline companies such as Daiichi Sankyo Company, Mirati Therapeutics, Apollomics, Treos Bio Zrt, AskAt, Effector Therapeutics, Menarini Group, ImmunityBio, Arcus Biosciences, Abraxis Bioscience, Chia Tai Tianqing Pharmaceutical Group, Aadi, LLC, BioNTech SE, Novartis, Immunovative Therapies, Transgene, Cardiff Oncology, Genentech, Sumitomo Pharma Oncology, GamaMabs Pharma, Qilu Pharmaceutical, Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd., PharmaMar, Suzhou Zelgen Biopharmaceuticals, Innovent Biologics, Sinomab, Yooyoung Pharmaceutical, Amal Therapeutics, Celleron Therapeutics, Merck Sharp & Dohme Corp, Isofol Medical, Surgimab, EpicentRx, Inc, Apros Therapeutics, Eisai Co., Ltd., Puma Biotechnology, G1 Therapeutics, Mologen AG, Celyad Oncology, Jiangsu HengRui Medicine, Evelo Biosciences, Sinocelltech, Moderna Therapeutics,  Sichuan Kelun Pharmaceutical Research Institute, Nektar Therapeutics, MedPacto, Karyopharm Therapeutics, Gritstone Oncology, Lumicell, Inc., IDEAYA Biosciences, Cantargia AB, NextCure, Inc., Lokon Pharma AB, Chongqing Precision Biotech Co., Ltd, Bold Therapeutics, OBI Pharma, Inc, Gritstone Oncology, IGM Biosciences, Rgenix, Inc., Precision Biologics, Inc, MacroGenics, Academia Sinica, Innovative Cellular Therapeutics, Merck KGaA, Lyell Immunopharma, and others.

 

• Promising Colorectal cancer pipeline therapies in various stages of development include Patritumab Deruxtecan, Adagrasib, Geptanolimab, PolyPEPI1018, Grapiprant, eFT508, MEN1611, Aldoxorubicin Hydrochloride, Etrumadenant, AL2846, ABI-009, RO7198457, Dabrafenib, AlloStim, TG6002, Onvansertib, BLYG8824A, Napabucasin, GM102, QL1203, CPGJ602, PM060184, Donafenib, IBI310, Spartalizumab, CMAB009, YYB101, ATP128, Vicriviroc, CXD101, Arfolitixorin, SGM-101, RRx-001, APR003, E7386, Trastuzumab, Trilaciclib, MGN1703, BBI608, CYAD-101, SHR-A1811,  EDP1503, SCT-I10A, KL-140, V941, NKTR-255, TEW-7197, MGD019, KPT-8602, GRT-C901, LUM015, IDE196, CAN04, NC410, LOAd703, CEA CAR-T cells, BOLD-100, OBI-833, GRT-C903, IGM-8444, RGX-202-01, NE-201, DS-8201, GCC19CART, M 9140, LYL845, and others.

 

• The Colorectal Cancer Companies and academics are working to assess challenges and seek opportunities that could influence Colorectal Cancer R&D. The Colorectal Cancer pipeline therapies under development are focused on novel approaches to treat/improve Colorectal Cancer. 

 

To explore more information on the latest breakthroughs in the Colorectal Cancer Pipeline treatment landscape of the report, click here @ Colorectal Cancer Pipeline Outlook

 

Colorectal Cancer Overview

 

Colorectal cancer refers to cancer in the colon and/or rectum, or both. As the graphic below shows, the colon is part of the large intestine or large bowel. The rectum is the passageway that connects the colon to the anus. Most colorectal cancers develop first as polyps, which are abnormal growths inside the colon or rectum that may later become cancerous if they are not removed. Colorectal cancer (cancer of the colon or rectum) is very treatable when it is discovered early. Even if it spreads into nearby lymph nodes, surgical treatment followed by chemotherapy is very effective. In the most advanced cases — when the cancer has spread to the liver, lungs, or other sites — treatment can often make surgery an option, and can prolong and add to quality of life. Research is constantly being done to learn more and provide hope for people in all colorectal cancer stages.

 

Latest Developmental Activities in the Colorectal Cancer Treatment Landscape

 

• In October 2022, Lyell Immunopharma announced that the US Food and Drug Administration (FDA) cleared its Investigational New Drug (IND) application to initiate a Phase 1 clinical trial for LYL845. Phase I trial to initially enroll patients with relapsed and/or refractory metastatic or locally advanced melanoma and subsequently expand into non-small cell lung cancer and colorectal cancer.

 

• In September 2022, Agenus announced the initiation of a global Phase II program of botensilimab, an Fc-enhanced anti-CTLA-4 that activates innate and adaptive immune responses. These trials include ACTIVATE-Colorectal, a Phase II study designed to evaluate botensilimab as monotherapy and in combination with balstilimab (anti-PD-1) for the treatment of microsatellite stable colorectal cancer.

 

• In September 2022, BioNTech announced that the first colorectal cancer patient had been treated with its individualized mRNA cancer vaccine BNT122 (autogene cevumeran, RO7198457) in a Phase II clinical trial.

 

• In August 2022, ALX Oncology initiated the Phase II clinical trial of evorpacept plus Erbitux (cetuximab) and Keytruda (pembrolizumab) in refractory microsatellite stable metastatic colorectal cancer (mCRC) patients. The combination treatment is intended for mCRC patients who have advanced following a minimum of two lines of systemic therapy.

 

• In August 2022, Celyad Oncology announced that the US Food and Drug Administration (FDA) lifted the clinical hold on the CYAD-101-002 (KEYNOTE-B79) Phase 1b trial after the Company made changes to the eligibility criteria for the trial.

 

• In June 2022, Exelixis announced the initiation of STELLAR-303, a Phase III pivotal trial evaluating XL092 in combination with atezolizumab versus regorafenib in patients with metastatic colorectal cancer (CRC) that is not microsatellite instability-high or mismatch repair-deficient, who have progressed after or are intolerant to the standard of care therapy. 

 

For further information, refer to the detailed Colorectal Cancer Unmet Needs, Colorectal Cancer Market Drivers, and Colorectal Cancer Market Barriers, click here for Colorectal Cancer Ongoing Clinical Trial Analysis

 

Colorectal Cancer Emerging Drugs Profile

 

Patritumab Deruxtecan: Daiichi Sankyo Company

Patritumab deruxtecan (HER3-DXd, U3-1402) is one of three lead DXd antibody drug conjugates (ADC) in the oncology pipeline of Daiichi Sankyo. Designed using Daiichi Sankyo’s proprietary DXd ADC technology, patritumab deruxtecan is comprised of a human anti-HER3 antibody attached to a topoisomerase I inhibitor payload, an exatecan derivative, via a stable tetrapeptide-based cleavable linker.

 

Adagrasib: Mirati Therapeutics

Adagrasib (MRTX849) is an investigational, highly selective and potent, oral small molecule therapy designed to shrink difficult-to-treat cancers harboring the KRAS G12C mutation. Currently, the drug is in Phase III stage of clinical trial evaluation to treat colorectal cancer.

 

Etrumadenant: Arcus Biosciences

Etrumadenant (AB928), the first dual A2a/A2b adenosine receptor antagonist in the clinic, is designed to maximally inhibit the adenosine-driven impairment of tumor-infiltrating lymphocytes (mainly CD8+ T cells and NK cells) and myeloid cells (dendritic cells, macrophages), mediated by A2aR and A2bR, respectively. A2bR is also upregulated by certain cancer cells, such as in prostate cancer and KRAS- mutated cancers. As a result, etrumadenant may uniquely block adenosine’s immunosuppressive and cancer cell-intrinsic effects.

 

AL2846: Advenchen Laboratories

AL2846 is a c-Met receptor tyrosine kinase (RTK) inhibitor and it also inhibits other RTKs of Flt4, KDR, Axl and Ron being developed by Advenchen Laboratories. Currently, the drug is in Phase I/II stage of clinical trial evaluation to treat colorectal cancer.

 

Onvansertib: Cardiff Oncology

Onvansertib is a First-In-Class, Third-Generation, Oral and Highly-Selective PLK1 Inhibitor. The drug is in phase 1/2 of clinical trials for the treatment of patients with colorectal cancer.

 

Colorectal Cancer Pipeline Therapeutics Assessment

There are approx. 150+ key companies which are developing the therapies for Colorectal Cancer. The companies which have their Colorectal Cancer drug candidates in the most advanced stage, i.e. phase III include, Mirati Therapeutics.

 

Request a sample and discover the recent advances in Colorectal Cancer Ongoing Clinical Trial Analysis and Medications, click here @ Colorectal Cancer Treatment Landscape

 

Scope of the Colorectal Cancer Pipeline Report

 

• Coverage- Global

 

• Colorectal cancer Companies- Daiichi Sankyo Company, Mirati Therapeutics, Apollomics, Treos Bio Zrt, AskAt, Effector Therapeutics, Menarini Group, ImmunityBio, Arcus Biosciences, Abraxis Bioscience, Chia Tai Tianqing Pharmaceutical Group, Aadi, LLC, BioNTech SE, Novartis, Immunovative Therapies, Transgene, Cardiff Oncology, Genentech, Sumitomo Pharma Oncology, GamaMabs Pharma, Qilu Pharmaceutical, Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd., PharmaMar, Suzhou Zelgen Biopharmaceuticals, Innovent Biologics, Sinomab, Yooyoung Pharmaceutical, Amal Therapeutics, Celleron Therapeutics, Merck Sharp & Dohme Corp, Isofol Medical, Surgimab, EpicentRx, Inc, Apros Therapeutics, Eisai Co., Ltd., Puma Biotechnology, G1 Therapeutics, Mologen AG, Celyad Oncology, Jiangsu HengRui Medicine, Evelo Biosciences, Sinocelltech, Moderna Therapeutics,  Sichuan Kelun Pharmaceutical Research Institute, Nektar Therapeutics, MedPacto, Karyopharm Therapeutics, Gritstone Oncology, Lumicell, Inc., IDEAYA Biosciences, Cantargia AB, NextCure, Inc., Lokon Pharma AB, Chongqing Precision Biotech Co., Ltd, Bold Therapeutics, OBI Pharma, Inc, Gritstone Oncology, IGM Biosciences, Rgenix, Inc., Precision Biologics, Inc, MacroGenics, Academia Sinica, Innovative Cellular Therapeutics, Merck KGaA, Lyell Immunopharma, and others.

 

• Colorectal Cancer Pipeline- Patritumab Deruxtecan, Adagrasib, Geptanolimab, PolyPEPI1018, Grapiprant, eFT508, MEN1611, Aldoxorubicin Hydrochloride, Etrumadenant, AL2846, ABI-009, RO7198457, Dabrafenib, AlloStim, TG6002, Onvansertib, BLYG8824A, Napabucasin, GM102, QL1203, CPGJ602, PM060184, Donafenib, IBI310, Spartalizumab, CMAB009, YYB101, ATP128, Vicriviroc, CXD101, Arfolitixorin, SGM-101, RRx-001, APR003, E7386, Trastuzumab, Trilaciclib, MGN1703, BBI608, CYAD-101, SHR-A1811,  EDP1503, SCT-I10A, KL-140, V941, NKTR-255, TEW-7197, MGD019, KPT-8602, GRT-C901, LUM015, IDE196, CAN04, NC410, LOAd703, CEA CAR-T cells, BOLD-100, OBI-833, GRT-C903, IGM-8444, RGX-202-01, NE-201, DS-8201, GCC19CART, M 9140, LYL845, and others.

 

• Colorectal Cancer Pipeline Segmentation: Product Type, Molecule Type, Route of Administration, Mechanism of Action 

 

Dive deep into rich insights for drugs for Colorectal Cancer Market Drivers and Colorectal Cancer Market Barriers, click here @ Colorectal Cancer Unmet Needs and Analyst Views

 

Table of Content 

1. Introduction
2. Executive Summary
3. Colorectal Cancer: Overview
4. Pipeline Therapeutics
5. Therapeutic Assessment
6. Colorectal Cancer – DelveInsight’s Analytical Perspective
7. Late Stage Products (Phase III)
8. Adagrasib: Mirati Therapeutics
9. Drug profiles in the detailed report…..
10. Mid Stage Products (Phase II)
11. Patritumab Deruxtecan: Daiichi Sankyo Company
12. Drug profiles in the detailed report…..
13. Early Stage Products (Phase I)
14. BI 905711: Boehringer Ingelheim
15. Drug profiles in the detailed report…..
16. Preclinical and Discovery Stage Products
17. AM 401: Altamira Therapeutics
18. Drug profiles in the detailed report…..
19. Inactive Products
20. Colorectal Cancer Key Companies
21. Colorectal Cancer Key Products
22. Colorectal Cancer- Unmet Needs
23. Colorectal Cancer- Market Drivers and Barriers
24. Colorectal Cancer- Future Perspectives and Conclusion
25. Colorectal Cancer Analyst Views
26. Colorectal Cancer Key Companies
27. Appendix

 

Got Queries? Find out the related information on Colorectal Cancer Mergers and acquisitions, Colorectal Cancer Licensing Activities @ Colorectal Cancer Emerging Drugs, and Recent Trends

 

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